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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 12, 2021, pp. 1085-1090
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Bioline Code: rm21113
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 12, 2021, pp. 1085-1090
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Evaluation of hyperprolactinemia risk factors in infertile women referred to Yazd Infertility Center: A cross-sectional study
Dehghan, Elahe; Namiranian, Nasim; Ghadiri-Anari, Akram; Ratki, Seid Kazem Razavi & Azizi, Reyhaneh
Abstract
Background: Hyperprolactinemia is one of the most common causes of infertility in
women. The prevalence of pituitary tumors is 25-30% among infertile participants with
hyperprolactinemia.
Objective: The aim of this study was to describe the causes of hyperprolactinemia in
infertile women referred to Yazd Infertility Center.
Materials and Methods: This cross-sectional study was conducted with 182 infertile
women with hyperprolactinemia who were referred to Yazd Infertility Center from
February 2018 to October 2019. Serum prolactin was assessed by the human prolactin
ELISA kit according to the Padtan Gostar Isar protocol. The age, duration of infertility,
causes of hyperprolactinemia, and type of infertility treatment were noted. The MRI
findings were added.
Results: The mean age of participants was 28.9 ± 0.36 yr and the prolactin level was
76 ± 8.97 ng/ml. The etiology of hyperprolactinemia among the study participants was
35 participants (19.2%) with pituitary adenoma, 47 participants (25.8%) with polycystic
ovary syndrome, 14 participants (7.7%) with pituitary adenoma and polycystic ovary
syndrome, and 86 participants (47.3%) with idiopathic hyperprolactinemia. The results
of this study showed that there was no statistically significant difference between
the mean prolactin levels in participants with different causes of hyperprolactinemia
(p = 0.31).
Conclusion: Idiopathic hyperprolactinemia and polycystic ovary syndrome are the most
common reasons for hyperprolactinemia.
Keywords
Hyperprolactinemia; Infertility; PCOS.
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