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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 6, 2016, pp. 32-37
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Bioline Code: tc16139
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 6, 2016, pp. 32-37
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MODULATION OF CARCINOGEN-METABOLIZING ENZYME BY MADINAH MINT ( Mentha spp) IN RAT LIVER
Malki, Abdulrahman L. al-; Barbour, Elie K.; Huwait, E.A.; Moselhy, Said S. & Choudhry, Hani
Abstract
Background: The present study was undertaken to assess whether boiling water mint extract (BWME) modulates the cytochrome
P450 mixed function oxidase system.
Materials and methods: Male albino rats were randomly divided into two groups, comprising 12 animals each. The first group
served as control, whereas the second was maintained on BWME (10 % w/v) as its sole drinking liquid for six weeks. Liver
microsomal were separated and subjected for phase I and II enzymes (cytochrome P450 mixed function oxidase) analysis
Results The results obtained showed that, BWME caused a significant elevation in the activity of epoxide hydrolase (p<0.001) when
compared with the control. However, glutathione S-transferase and glucuronosyl transferase activities were significantly decreased
(p<0.001 and p<0.01) respectively compared with control. The mutagenic activity of N-nitrosopiperidine was lower in the mint-treated
hepatic microsomal compared with the controls.
Conclusion: It can be concluded that BWME has the potential to suppress the activity of cytochrome enzymes involved in the bioactivation
of chemical carcinogen; hence may display chemo preventive activity.
Keywords
Carcinogen-PAH-Cytochrome P450
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