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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 5, 2017, pp. 113-120
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Bioline Code: tc17065
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 5, 2017, pp. 113-120
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EFFECTS OF GLYCYRRHIZIN PRE-TREATMENT ON TRANSIENT ISCHEMIC BRAIN INJURY IN MICE
Lim, Chiyeon; Lim, Sehyun; Lee, Young-Jun; Kong, Bokcheul; Lee, Byoungho; Kim, Chang-Hyun; Kim, Buyeo & Cho, Suin
Abstract
Background: Ischemia-induced brain damage is the leading cause of adult disability and the fifth leading
cause of death, and thus, the development of anti-apoptotic neuro-protective therapeutic agents is viewed as
an attractive developmental strategy. Glycyrrhizin is the main sweet component in licorice and has a number
of pharmacological activities, which include neuro-protective, anti-fungal, and anti-cariogenic activities.
This study was undertaken to investigate the effects of glycyrrhizin on ischemia-induced brain damage.
Materials and Methods: In infarct volumes and the levels of several apoptosis-related proteins, caspase-3, -8, 9, Bcl-xL, Bcl-2,and their activities in the brains of middle cerebral artery occlusion (MCAO) treated mice
were measured using western blotting methods.
Results: Single pre-treatment with glycyrrhizin (10-100 mg/kg)at 2 hours before MCAO significantly
reduced infarct volumes at 24h after MCAO. In addition, glycyrrhizin effectively inhibited the activations of
caspase-3 and -9 and the down-regulation of Bcl-xLprotein caused by MCAO.
Conclusion: The neuro-protective effect of glycyrrhizin was found to be due to its regulation of apoptosisrelated
proteins signals.The authors suggest glycyrrhizin be considered a potential candidate for the
treatment of ischemia induced brain damage.
Keywords
Glycyrrhizin; licorice; stroke; apoptosis
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