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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 3, 2017, pp. 42-50
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Bioline Code: tc17080
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 3, 2017, pp. 42-50
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ANTI-DIABETIC EFFECTS OF ZHUODUQING FORMULA, A CHINESE HERBAL DECOCTION, ON A RAT MODEL OF TYPE 2 DIABETES
Feng, Xiao-Tao; Tang, Shu-Yan; Jiang, Yun-Xia & Zhao, Wei
Abstract
Background: Zhuoduqing formula (ZDQ) is a Chinese herbal decoction and used to treat type 2 diabetes in clinical
practice, but the potential evidence needs to be provided.
Materials and Methods: Type 2 diabetic model rats were induced by feeding high fat diet (HFD) and intraperitoneal
injection of streptozotocin (STZ). The model rats were given ZDQ for 4 weeks. Insulin sensitivity was evaluated by
homeostasis model assessment of basal insulin resistance (HOMA-IR) and intraperitoneal glucose tolerance test
(IPGTT). Blood insulin and tumour necrosis factor-α (TNF-α) levels as well as SOCS-3 levels in skeletal muscles were
analyzed by ELISA.
Results: ZDQ significantly decreased fasting blood glucose, ameliorated HOMA-IR and IPGTT, and reduced
triglyceride and total cholesterol in type 2 diabetic rats. Moreover, ZDQ remarkably lowered blood TNF-α levels and
inhibited SOCS-3 levels in skeletal muscles.
Conclusion: The results display that ZDQ performs anti-diabetic functions in type 2 diabetic rats induced by feeding
HFD and intraperitoneal injection of STZ.
Keywords
Insulin sensitivity; Chinese medicine; anti-diabetic effect; inflammatory factor; SOCS-3
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