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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 3, 2017, pp. 187-193
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Bioline Code: tc17095
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 3, 2017, pp. 187-193
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SPATHOLOBUS SUBERECTUS STEM EXTRACT IMPROVES THE PROTECTIVE EFFECT OF HEPARIN ON CERULEIN–INDUCED PANCREATITIS
Shao, Zhengyi
Abstract
Background: The present study evaluates the effect of Spatholobus suberectus stem extract (SS) in the management
of pancreatitis alone and in combination with heparin.
Material and methods: Pancreatitis was induced pancreatitis by cerulean (50μg/kg, i.p.) five times at an interval of 1 h
without any pretreatment of drug. Rats were treated with SS (100 and 200 mg/kg, p. o.) and heparin (150 U/kg, i.p.)
alone and in combination for the duration of a week. Later pancreatic weight and blood flow was estimated and
different biochemical parameters like concentration of D-dimer and Interleukin 1β (IL-1β) and activity of amylase and
lipase were determined in blood of pancreatitis rats. Moreover effect of drug treatment on DNA synthesis and
histopathology was also estimated on cerulean induced pancreatitis rats.
Result: Results of this study suggest that treatment with SS alone and in combination with heparin significantly
increase in prothrombin time and pancreatic blood flow than negative control group. There was significant decrease in
concentration of IL-1β and D-dimer and activity of amylase and lipase in SS and heparin treated group than negative
control group. Pancreatic DNA synthesis was also found to be reduced in SS and heparin alone and in combination
treated group. Histopathology study also reveals that treatment with SS and heparin alone and in combination reduces
edema, hemorrhages, leukocyte infiltration in the TS of pancreatic tissues.
Conclusion: Present study concludes that
treatment with SS alone effectively manages the pancreatitis by ceasing the inflammatory pathway and potentiates the
effect of heparin in the management of pancreatitis.
Keywords
Spatholobus suberectus; Pancreatitis; Pancreatitis; Cerulean
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