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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 3, 2017, pp. 209-217
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Bioline Code: tc17098
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 3, 2017, pp. 209-217
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INVESTIGATION ON CHEMICAL COMPOSITION, ANTIMICROBIAL, ANTIOXIDANT, AND CYTOTOXIC PROPERTIES OF ESSENTIAL OIL FROM DRACOCEPHALUM KOTSCHYI BOISS.
Ashrafi, Behnam; Ramak, Parvin; Ezatpour, Behrouz & Talei, Gholam Reza
Abstract
Background: Dracocephalum kotschyi Boiss is a herb with wide-spread applications. Lorestan traditional healers have
applied it for the treatment of rheumatoid diseases and stomach disorders.
Materials and methods: Hydrodistillation process was used for essential oil extraction, the extracted essential oil was
then analyzed through combination of capillary GC–FID, GC–MS and RI. The in vitro antimicrobial, antioxidant and
cytotoxic activities of this essential oil were examined. Results indicate that the essential oil has a broad range of antimicrobial activity against all of the tested microorganisms.
Results: The 50% of cytotoxic concentrations was 26.4 μg/ml and 4266.7 μg/ml for Hela cells and human
lymphocytes, respectively. The oil cytotoxicity against the human tumor cell line was far higher than the amount
required for human healthy cells. Conversely, the essential oil’s IC50 value of 49.2 μg/ml in the DPPH assay, could be
regarded as its strong antioxidant potential.
Conclusion: According to the data obtained, it can be concluded that D. kotschyi essential oil could be applied as a safe
antibacterial and antioxidant agent for food and pharmaceutical purposes.
Keywords
Antimicrobial; Antioxidant; Dracocephalum kotschyi Boiss; Cytotoxicity; Essential oil.
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